Dice : The dice mechanics can feel punishing, irksome, and absolutely lethal. I mean it, every time any sort of check shows up I feel nothing but dread because I didn't save for a good while and rolling a 1 will mean potentially getting annihilated by an angry mob of fish people and their "god". Likewise it also means a LOT of saving and loading. Having to save scum every time the dice arbitrarily decide to kill me or jip me out of something good feels pretty lame man, especially because the load times are not grand.
I hate the way dice is implemented. It makes sense in a tabletop game, where DM can explain why your character failed a skill check in a way that makes sense. But in the game, it feels like "Oh, my 16 Cha Warlock failed a persuasion check with a goblin. Did he fart during his speech or something?". Passive skill checks are fine, but the active ones are a pain to deal with.
Good thing about that is that Larian has already promised to look into the checks in conversations and make sure you don't flat out lock yourself out of content just because you rolled bad once.
But what Larian (as the DM of this game) could also do is re-adjust some of the DC's and make some of them more believable.
But then again, at the end of the day a bad roll remains a bad roll, but maybe they can find ways to make even failures more enjoyable for the player to ease the frustration a little more. Maybe with adding some "fail-safe" talking points or quests that you get for a bad roll and completing them could help you getting back on track.