Hei, I know I'm super late but...
I would rather have a confirm popup for the reaction/s too, I don't like to pre-cast spells like Hellish Rebuke since you might need that spellslot for something else, what if they don't attack you at all?
The popup could show only IF the reaction is toggled on the panel AND triggered AND effective (example, Shield would ask confirm only if you could avoid the attack by casting it or if targeted by Magic Missiles). Everything you could use as a reaction should appear toggleable on a panel (if you have the spell prepared etc)
The Confirm Popup would just show the list of the possible reactions (if toggled + triggered + effective) and a button "skip".
Probably the game will be slightly slower, but for sure more precise and if you don't want to take this kind of reactions you can just toggle them off.

I personally don't like the idea of "configurable reactions" cos it would need too many cases, what if Shield is triggered by the last mob with 1hp attacking with a dagger? How'd you configure Counterspell?
I'd be ok if this is an option but I'd still prefer a more "manual" approach.