It's been 100.2 hours on ultra settings over the past several days and so far and I haven't bumped into anything especially game breaking until the 90-ish hour mark.
As it stands...
Load times have become concerningly long, the amount of time it takes to save has also dramatically increased, the game stutters at every other turn (and worse in the rain) and the act of loading a save tends to result in the game or even my whole computer crashing.
I have tried most of the usual troubleshooting suggestions: cleaning up my computer, disabling firewalls, ditching any potentially interfering programs, reducing my graphics settings to the bare minimum, deleting certain files and having steam verify the integrity of said files to replace them with fresh ones.
None of it has worked so far.
If anyone knows a fix for this particular problem I'd be much obliged.