They make it harder for me to maintain situational immersion, if there is such a term. I enter a room, possible dangers or important story characters are present, but first I have to vacuum the room, looking in every box and broken vase, before "getting back into character". It's not something I can help, so it's not a choice. I had it the same way with D:OS, but those games also had way too much loot, BG3 doesn't, it's just all the empty crates.