I think thy did it right on Vampire the Masquerade Bloodlines, where you had to stay in the shadows as a Nosferatu (a Clan that is horrible disfigured) and people react to your Malkavian (a Clan that has mental issues). I would love for something similar here.
That game was great.
The best - and I think, they really handled playing the different clans very well. YOur conversation as a Toreador with Gary Golden or the constant distrust from nearly every vampire npc as a Tremere or the caution, if you play Malkavian ('what does she know about me'?) is just great.
I would like to see something similar in BG3. There are some moments, where it is done well - for example with the tieflings that caught Lae'zel. If you approach them as Githyanki or Drow, they are ready to attack on sight, your only hope is to intimidate them.
But other than that, tehre is no drawback or change, if you play those two races.
