I have a few major issues to report.
Firstly: Gales quest is gone. Just completely not there. At the party he talks as if I have given him artifacts to absorb, but I haven't. He never asked me to, and in fact I never had any cut-scenes with him at all. This has never happened before. Also he does not want to romance me. Which makes me sad. Even though his approval is "Very High".
Secondly: Wyll's quests still does not work, but it never did for me. He never tells me of Mizora, and pretends he never talked to Spike.
Thirdly: The underdark is a maze of crashes and corrupted save files for me. Ever since I went down there my game will crash regularly, and then the two newest save files I have made get corrupted, forcing me to load a decently old file every time. I think it has something to do with the Myconid colony, as that is where the majority of the crashes happen. One did happen back at camp however.
Fourthly (Is that a word?): Some good things. The burning inn now works for me. No crashes or corrupted files for the first time, and the quests can be completed. The top-side is generally much more stable now than it has ever been for me.