I have encountered two issues with companions so far, which were not present in my game in the previous patches:
Firstly, Astarion's dialogue after the first tadpole dream (where he is supposed to reveal that he saw Cazador) gets cut off abruptly before the player can pass or fail the Perception check. There aren't any conversation options or narration, the game just suddenly goes from a close-up of Astarion's face to the regular view of the camp.
Secondly, the goblins in the Blighted Village (specifically those that torment the Deep Gnome at the windmill) do not react to Wyll's presence in the party. There are no cutscenes with Wyll where he demands to know where Spike is, and the Blade of Frontiers quest does not update as it should.
I am interested to know if anyone else started running into these issues after Patch 4, especially the glitch with Astarion!