I gave the book to gale initially, but now he doesn't seem to realise it's in his inventory ...he says "you have such an item!" (and won't give it back to me to give to him). That can't be intended? I mean he goes on about needing powerful magic item....and when I had it last playthrough and he requested it, things worked as they should.
I always give Gale the book from his own dialogue menu, not the book's menu, and he's nommed it happily every time (though in previous patches the quest wouldn't update properly). You could give that a try, if you haven't already.
Astarion's new cutscene is a treat. I still feel kinda guilty if I give him the book instead of Gale, I can't help thinking our pet vampire is in over his head with that tome.