Might be a dumb thing to say, but some games revel in the mortality of NPCs.
For example in Morrowind you can kill Vivec. This is considered a really bad result and the game warns you that you doomed the place, but you can just keep playing in this doomed world and as far as I know you can still beat the game.
Similarly you can kill NPCs in dark souls series to get certain items or progress early. The murdering of an npc is rewarding but also affects the game as now I have to contend with a high level boss at a low level and various npc summons get locked away as an example. Or I get their weapon but I ruined their questline or can not learn newer spells from them.
And then there is New Vegas which is designed with the ability to kill everyone (except yes man) and you can drastically affect faction relations like that. It is possible to murder Caesar and still lead the legion to victory under a new leader, or let/cause the NCR president die and lead the NCR to victory.
In short, I am hoping BG3 becomes that kind of game where death can be a major factor in how you engage with people, do you chaotic evil murder them for the reward you want now, or deal with them as a lawful good and navigate the quest that way.
