Had this issue today with windows 10. Did a little research and found out that repairing Microsoft visual C++ could work. But even then I had to go E:\Program Files (x86)\Steam\steamapps\common\Divinity Original Sin 2\Defed\bin
The EoCAPP.exe worked, so I sent a shortcut to the desktop. A little frustrating that it took most of the afternoon to get it to play after it worked fine last weekend. 🤕