I have had a horrible time lock picking on my Drow thief (17 dex and proficiency in slight of hand so +5) as well as Astarian since patch 4, and doubly bad since Hotfix 10. I HAVE TRIED WITH >>>> AND WITHOUT LOADED DICE. Each failed attempt uses 2 lock-pick kits , and I have gone on strings of 9 attempts (so used 18 kits) then go back to save point and do another 9, etc.. up to 3 sets of 9 and still failing every single attempt. So this seems an obvious bug in either the RNG, or somewhere else. This happens on doors, gates, and chests. The only solution seems to be to fail, then return to save, try again, and repeat ad nausium till it eventually succeeds. And this can take several trys to get it done, which makes me start to really hate that long loading screen after awhile. Lockpicking in the current patch is totally borked.