Just preventing you from putting it in your backpack would go a long way
Yeah, said the same thing already months ago.
It would be nice, quick and dirty fix to have either some of these barrels either as stating objects in the scenario you can't really move around OR to make moving them around a slow, cumbersome and somewhat awkward job, like in Shadow Tactics when the you use the big samurai (the "muscle" of your team) to carry a single barrel from a place to another.
Also, if we want to put the icing on the cake, it would be top if NPCs (or at least CERTAIN types of NPCs) would reacted when you are placing explosive shit like barrels suspiciously close to their position.
In a similar way as they already do when they see you stealing stuff/sneaking around them.