I'd rather savescum until I get the result I want, roleplay-wise. If I have a character, an idea of what would/should happen in the story or conversation with a companion, it would be so frustrating to be locked out of something important halfway through the game just because the dice said so. After all, it's not a tabletop DnD game where you defer to the will of the dice, it's my personal computer game and I'll play it how I want to. :P
If I want a "ruled by the roll of the dice" game I would set aside a separate playthrough and see where lady Luck takes me.
