Whilst I agree on BG2 loot vs DOS2 Loot, I will add that a degree of randomisation can be fun.
For example, if the World or Act was populated with some random items at game start (and couldn't be changed by re-loading), then I would quite enjoy that. I.e. Location A known to have a Longsword +2 on this play through rolls a Rapier +1 (with added Fire damage) for example. That way re-exploring certain areas on multiple playthroughs has some additional appeal and one looks a little closer at the drops without having the DOS or Diablo feel of changing items every 5 metres.
Obviously not for every item, there need to be specific items that people can count on and build their characters around/ rejoice at finding, but yeah; I am not against randomised loot per say, just within the feel of a BG game.