Okay, I got the hotfix and tried to play maybe less than 5 minutes then a windows blue screen was triggered . Never happens before. OS is up to date. I'll try to upgrade my nvidia pilotes and try again.
Not sure if this is feasible with your current internet plan/connection speed but have you considered doing a clean install of the game? I always do this when a new patch (not hotfix) is released and while I can't vouch that this solves all problems, I haven't experienced any crash so far (RX 480, latest WHQL drivers).
My game is on GOG so I already had to make a clean install to get patch 5 ^^ (And as I used mods, I always did a clean install of the game for every new patch, just in case)