Astarion doesn't even sound like an actual person. He sounds almost like someone who's parroting his gay friend in mockery.
Incidentally I've seen interviews with his voice actor and his natural voice/timbre is entirely different and sounds far more pleasant.
I totally agree, Astarions voice is awful (and the character too). He does sound totally fake.
Another voice actor , I like, is Zevlors. He does a good job.