In DOS 2 you could wipe out entire cities and they would stay that way and never recover.
What I am really talking about is legitimate boundaries. Enemies you cannot expect to defeat without cheating or getting extremely lucky.
You're forgetting that DOS2 had different system, where you can keep on going without resting at all. And you're nearly a god capable of creating storms of blood and rotten meat in DOS2 when you reach Arks. In D&D you can actually overhelm a high-lvl murder-hobo PC with just more battle units.