They do attempt a lot of suicides with all that jumping back and forth. Jumping up the illusionary mushrooms appear to have become impossible except via jump or misty step spells too.
oh and the well in the burned village is broken. I could enter once, but not again. And i burned the web from the smith into the underground. My str 18 dwarf wizard and Laezel could still jump and Astarion did a misty step. Well maybe i could kill the big spider with 3? Shadowheart could (once grouped) run around and meet you in the spidertunnels.
The game claims its a "cannot reach" issue. Something bothering a lot of minor places like a necklace in the zent hideout, painting in waukens rest & more.
Noticed the diplopath for gith is now actually doable with skillhelps (other than just requiring insane luck). So yeah friends is powerful, but diplomacy is in the real world. I mean loads of people in positions their skills never should allow them to access, only there in wealth, power and and influence because they can persuade like a cha 16+friends+guidance & skillbonus diplomancer.