Can you use two metamagic abilities on the same spell in BG3? I didn't try that and I guess the lack of sorcery points at level 3 makes it impossible anyway.
A double Fireball alpha strike at level 5 sounds like a balance nightmare. But a level 11 Sorcerer casting two Twinned Disintegrates sounds completely bonkers. An enemy Sorcerer could Disintegrate 4 PC's before anyone gets a turn. And if you can't... "just" a double Disintegrate on the same target also sounds like a balance nightmare.