Yeah, I've noticed some really intense frame drops, most noticeable in the tiefling cave where Zorru stands, and in the Blighted Village in the necromancer's cellar when you pick up the book. I think it has something to do with the new lighting system, when the camera is in front of the character and a complicated light source is behind them, I'm getting majorrrr lag, like 15 FPS, when pre-patch 6 I could run the same scenes at 60FPS.
I'm also noticing during location transitions, like the end of the nautiloid cinematic, after the loading screen it will briefly show my character on the beach before loading the cutscene where Ragzlin and Minthara are watching the nautiloid crash. I think maybe they're fully loading the world and then playing the cutscenes so that they play smoother, and I have noticed less stuttering in the cutscenes, so I guess it's a double edged sword. Hopefully they iron out all these bugs in a hotfix soon.