It's an odd one because, due to the visible components of the spell, using it right in the middle of conversation should cause issues... especially if it's someone else reaching over to put a hand on you and shouting "Guidance!" (looking at you Jester ^.^)

At the same time... It's very easy to see someone in the middle of a converstion, or example: Throwing up their hands for a moment in exasperation and saying "Oh, for the love of Bahamut would you please listen to me... We need to [etc.,]" that kind of thing wouldn't even raise eyebrows in OUR world (aside the the deity of choice mentioned), and seems like an every-day enough kind of thing.

It is definitely strange getting guided by the very person you're trying to persuade, however...