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In my opinion, the game doesn't have to be 100% DnD just based on it is fine. DnD is based on existing lore, they just tweak it for their own. So, Larian can also do the same for a video game.
pretty sure a lot of people who are hardcore DND tabletop players would strongly disagree on this.
I can say with complete confidence that this is actually the case. I've been to many gamecons and have met with members of Wizards of the Coast as well as some of the original designers of DnD and they have often pointed out that DMs are free (and encouraged) to modify or adjust rules and lore if necessary. The idea has always to be true to the spirit of the game. Variation is key to making the game always seem new and unfamiliar. The last thing any DM wants is the game to be so rule locked that the players end up just following a list of steps to win.
Predictability has never been the foundation of a fun game.