Most likely single player for the most part. Generally in Larian games I always do singleplayer first to get a full experience from start to end; Unless there's a reliable real life friend that I can have enough confidence in that will see it through with me. Though doing this in Dos2 made me realize that singleplayer first is probably always best, because my friend was heavily into crafting and min-maxing with vendors at any given opportunity. So our run ended up taking 162 hours when it should easily have been around ~100. Meaning I spent several tens of hours standing around twiddling my thumb, waiting for my friend.

For replays though, multiplayer is always fun!