Well, individual games are (assuming no funky cross contamination of files) individual state engines, so one play should not affect in the game engine what goes down in another one.
But your meta-knowledge - the things you know that the game character does not - i.e. that dialogue choice A produces result B - remains, of course.
Hope this helps!
Last edited by Nephtu; 02/12/21 05:19 PM. Reason: Typing is HARD....