I, for one, hope that hotbar management changes. Locking the hotbar (and unchecking stuff in a separate menu) can work for a while. As the characters progress there are more things to choose from and it would be great to have the ability to expand the narrow hotbar in order to organize things. Perhaps it could be given it's own UI page...

Otherwise, locking the hotbar is good until it isn't. Since the game isn't capable of knowing when I want it locked and when I don't there should be more features to it. Being able to "freeze" certain rows (or maybe just single squares), for example, would make things easier. I leave the bar unlocked because, early on in the game, I want stuff added automatically but as I get more stuff I notice that things in the hotbar start shifting around. "Freezing" squares is a good way to have locked and unlocked at the same time.