Dunno ...
I gues it would be just as meaningfull as when you first time enter a house you just buyed in other game, you just (wich some luck) will not need to buy it ... unless some greedy bureaucrat in town doesnt nationalize all your possessions allready.
I mean its not *you* returning home ...
Its your character returning home ...
Doesnt really matter if that is his own house, city s/he lived in, country or continent.
I mean i dunno, it just dont seem necesary to "spend some time before the game even starts" in there. O_o
First time i entered Breezehome in Skyrim, it was for both me and my character first time we have seen it ... and yet it felt like home allready.
First time my Exile set her feet on Ebon Hawk in SW:KotOR, it was just for me, since she flyed on that ship previously ... and yet it felt like my own ship.
First time i re-entered "my home" in Fallout 4, i remembered that i spend there few minutes before prologue ... and i never felt home there, not even close to how i felt in Red Rocket gas station.
I mean there are other ways to let us feel like home ... even if it will be first time we shall see the house and even if we will be able (and will do) to change everything there.
