I'm guessing it's a D&D/Wizards of the Coast choice over Larian. The divinity series had Drudanae, which I believe did different things throughout the series. That said, it was highly addictive, illegal, and with alchemy could make "drug" potion. Still not smoking, but a non-alcohol drug added into the lore.

I honestly don't know all the items in D&D to be able to compare. But there are subtle hints as others have pointed out to alternatives beyond alcohol.