Companions have nothing to say anymore at camp on Night 2 after Gale does his Mirror Image scene and talks about symptoms. Astarion used to say, "I saw you getting a lecture from our magical friend," and he'd ask about how he should kill you if you turn for example.
If I have Gale and Astarion in my party and Gale has told me about his need for artifacts, when I pick up the Necromancy of Thay, Astarion has no comment on it (he doesn't say "Why don't you let me carry it for you?") and I cannot give the book to him once I put the amethyst in the cover. I can only give it to Gale or read it myself. I reloaded an earlier save and the same thing happened again.
The talk with Volo once you get Gribbo to leave and you release him has him repeat several lines of dialog twice. The narrator also repeats her lines twice when you are examining Edowin's body and see the tadpole come out.
The spell Halt makes a weird rectangle grid on the target with a color picker on it. Seems like some image is missing.
If you sneak and lockpick the door into Priestess Gut's back room where the ogre is guarding, then leave and go back into the main temple interior or warp to the outdoor goblin camp, you will be trapped in an endless dialog loop with the nearest NPC telling you to leave because you're trespassing and you can't end the conversation even if you say "okay I'll leave." Either that or you will get stuck with a goblin trying to put you in prison and you can bribe him or persuade him, but you're stuck in a dialog loop until every line is exhausted and you're forced into combat.
When I load a saved game, the fog of war comes back on every map turning them completely black like I haven't explored anywhere.
