That is just matter of taste ...
Personaly i dislike those empty unuseable space ...
I would say of one looks a game and concludes that places not covered by UI are unusable spaces then it's quite a failure of the game! One would hope that the UI would be covering the game space, not be it.

Dunno ... i gues it depends on extend of definition. :-/
Il try to rephrase ...
I like to have separate interface screen, and separate part of screen where scene is happening ... i have no uses for gaps of scenery in between of UI (with exception of that big one in the middle, obviously) ...
Especialy if UI is not big enough so i can get there everything im using. :-/
I dunno how many of you do that, but i dont search for enemies in the corners (wich seems like the only possible use of that space) ... i simply move the camera to see them properly in the middle. :-/