And then can't tell whether the vector it's projecting for you is including moving your character or not - because you can't see them both at once, and the game might or might not be auto-moving your character as part of targeting that enemy, with no way of knowing - because if you slide the camera back to check, you're no longer mousing the intended target! Thanks Larian! Professional design!
Well ... personaly i solve this by rotating the camera and adjusting the angle so i see both my character, and the enemy.

So far i didnt find any place where that would be impossible (except for spiders cave, when you are down and spider several levels abowe you ... that place was a horror in previous patches ... not sure how it works now since it is quite long when this situation happened to me last time)
The camera is an issue for me in many places. As someone who pretty much only plays ranged characters and prefers tactical placement of AoE spells, it is a nightmare to do almost anything. Even in the ruins, where there aren't many levels it is an issue because if I have characters around the corner up by the button, I cannot see some of the enemies without moving my camera around, but due to the lack of Z axis I then cannot see my attacking character like I should be able to. Sure, I can walk down the stairs and be exposed from all sides like an idiot just so the camera can be used to see everything, but that is not fun for me at all. Not being able to see if your character needs to move to attack someone or if the attack is blocked by something is ridiculous.
As for the new hotbars, I have uninstalled the game (needed the space) until they allow us to arrange everything on all bars how we want it and hopefully bring back the option to make the bars bigger. I could tolerate it slightly on a non caster because there aren't that many things to click on, but with all the rest of the micromanaging (toilet chain especially) that has to be done, having to constantly search for stuff on the bar is too much. I want to play the game, not waste time memorizing some illogical layout of buttons.