Every interaction in the game needs to be achievable with just a mouse as a baseline. For accessibility if no other reason. You can of course have more complex interactions as well.
Ohhh, that's what you mean. Well, I can definitely suggest a couple of extremely clunky and convoluted ways to do it, potentially using just a single mouse button, and hopefully larian will pick one of them up. If people manage to write programs in brainfuck, this should be child's play.
Jokes aside, I'm not sure where did you pick up such a requirement. How about games that only work with controllers? I mean, it can't be an industry standard.
Do they have a mouse on Stadia?