I figured that un-pickable doors didn't actually have locks, but were barred, openable by a mechanical lever. But of course you can find keys for these doors, can't you? I hate it when I kill my own argument. Maybe they're computerised locks, like on expensive cars... <img src="/ubbthreads/images/graemlins/rolleyes.gif" alt="" />
The initial character selection should have a much bigger impact on the game. This could be why they removed the selection from RiftRunner, to avoid further disappointment. In D&D, your character's history is often used against the player and implemented into the story by the DM. Since Larian has created six pre-made characters to chose from, there should be stages where this affects the story. It would add a bit for replayability too! Survivors could receive bonuses in the poor area by being able to sympathise. Like DAD said, the female warrior made her reputation by killing a Blacksmith. Perhaps all Blacksmiths should start with a -25 attitude towards her. The "pretty" female Wizard should have strong moral objections to the Prostitute's Guild.
A simple change in initial reputation for each social class and profession would reflect a lot of the past experiences of each character. Although more could be done with time.