I did some "testing" and found that it may be too many save game files on a profile. I have a LOT of save games on my original profile. Just as an experiment I created a new profile and started a new game, clean, no previous saves. Seems to work. I've experienced no crashes so far in the new profile while my game was crashing around every 3 saves in my original profile.
It would be nice if this is the issue to limit the saves in a profile, warn us when the limit is near, ask us to clear space by making it easier to delete old saves, etc.