So far it seems that as long as you DONT:
- use any food
- interact with any vendor
- dont loot things you are not going to litteraly "use" (someone had problems with crashes caused by possessing a skull)
Then you should be fine.
Some people, me included, have also had reports of advancing companion's quests (for me it's giving artifacts to Gale, another user here pointed out that after Astarion's camp-event the game started save-crashing) will make the game crash on saving. So adding that to the list and maybe try to keep companion interaction to a minimum as well?
