Some people, me included, have also had reports of advancing companion's quests (for me it's giving artifacts to Gale, another user here pointed out that after Astarion's camp-event the game started save-crashing) will make the game crash on saving. So adding that to the list and maybe try to keep companion interaction to a minimum as well?
Damn ... at this rate, the will soon be stable only as long as we stand on beach and enjoy the scenery.
