In short, yes.
The
Official FAQ (pinned in this subforum, at the top) has this to say :
Is it the sequel of Baldur's Gate 1 and 2?
Yes. The story takes place 100 years after the events in Baldur’s Gate 2 and shortly after the events of Descent into Avernus. We don’t want to spoil anything about the story but it will be connected to the previous games in meaningful ways.
Also, in the Early Access content, we can find occasional references to the Bhaalspawn saga/crisis. In lore books, as far as my personal findings were concerned.