Shadowheart: They need to give her different armour probably, although I will say that a random commoner for instance would not know what a follower of Shar is likely to be wearing. Many people would rather have a somewhat normal backstory rather than something grandiose and filled with self importance, but a cleric should get a religion roll for sure with her current armour.
Astarion: Desperation makes people do stupid things. He is confused, probably traumatized, maybe even hungry, and not thinking clearly. He also says he saw us on the ship and thinks we are in league with the mindflayers, so even though he is outnumbered he will try to kill his assumed enemy. Not sure he would know that Shadowheart is a cleric unless she starts casting. Perhaps for this first meeting there could be another roll to determine if he will attack us or not (maybe from the response we give him?) As for all the other stuff about him, I feel like Larian didn't do enough research on how a vampire spawn really is. The spider climb part is easy though, we have no z axis. I just hope the rest can be explained properly later on because "tadpole" seems to be a big excuse for a lot of things.
Gale: I think his comment is referring to before we wake up on the ship. Hopefully what happened to get us there will be revealed later on in the game. A couple patches ago I am pretty sure that as a Drow I had a memory of something that implied I was being sacrificed but could be wrong about this. Perhaps all of our characters had something similar happen or just tried to fight when we were abducted, which would explain the blood. We do need to be able to ask Gale about why our tadpoles do not do what they do with everyone else, hopefully this also will be revealed later. As for killing him immediately, I have never done this (usually just don't go to the portal if I don't want him in my party) but if we don't get the resurrection scene then that is something that makes no sense and should be fixed.
Lae'zel: There should be some sort of dialogue to explain why she is now ok with not doing what she wants. It is weird that she suddenly accepts not going to the creche.
Wyll: He should also have a dialogue explaining things.