My vote is they move away from the Sword Coast entirely. The continent of Faerun is huge. The world of Toril is even larger. And the freakin D&D universe with it's multiple planes is incomprehensible vast. Oh, and D&D 5e also includes a multiverse that includes all possible settings!!
The Sword Coast is good enough, sure, but I've traveled up and down it so many times over different modules and video games. Let's get something new.
