My stance on this is that I sincerely hope Larian didn't start development fully assuming that they'll be making BG4 after this. We all know how well that worked out for the Pillars of Eternity series. I imagine a subset of the Larian fanbase wants them to go back to making DOS3 afterwards
I've been thinking about this for a while and I concluded that I wouldn't probably be able to go back to play another "DOS" unless Larian starts taking cues from what they are learning while doing BG3, from D&D or from other relatively similar pen & paper systems.
While all things considered my opinion of DOS 2 remained fairly high overall, after being done with it I don't think I could stand another game with the same "pits" in its core design.
The itemization, the progression curve and stat bloat, the armor system, the overuse of surfaces and explosives at every corner, the excessive hyper-mobility of everyone making basically the layout of the battle arena irrelevant... These are all elements I would dread to have to face again in their next product.
For all my minor gripes about the current state of BG3, I still find it a massive improvement over what they did with DOS 2 in most areas. And there's room to make it even better.