was thinking about how 6 players might work, and the ui is a big issue I see here. Unless they designed it from the start to be expandable (narrator: they didn't), it would be so much work to change everything. I just can't see them doing it. i can't even imagine how many systems are possibly tied to the four players either. Who knows, the toiletchain system might completely break if more players are added in. It takes a lot of extra effort to make something expandable vs static if you didn't start with that in mind.
Mods are really the only way I can see it happening
The game/UI already works fine with 6 in many places; you can start a session with 4 PCs and then get both Lae'zel and Us (and maybe even SH for 7??) added to your team in the tutorial. There are a few instances of the game where this doesn't work - e.g., on the underdark boat the game apparently kicks out (kills? deletes?) the 5th+ members of your party.
Edit: This is all 2nd-hand information I've seen others post about. I myself haven't tried it.