Also... what about a completely new setting?
https://en.wikipedia.org/wiki/Dungeons_%26_Dragons_campaign_settings
Which would people choose?
Hard to say... I'd love a real RPG set in Al-Qadim or the Birthright setting. Both had previous video games taking place in their settings, but none was an actual RPG.
Dark Sun would be another setting I'd love to play in again, though I'm not sure how well it would translate to 5e and the current philosophy at WotC.