Larian homebrew and gameplay - I loath them by now. There has yet to come one of their changes that I think benefited the game and wasn't just outright bad.
I already seem to not care at all about companions and most likely won't use them (would be a first for me, I always play with with original characters, but in this game I'm pretty sure I will switch to custom party out of the gate).
Story so far has been underwhelming by everything being over the top, but lets wait and see.
I must admit at this point I'm not worried about the game as much as I would end up surprised by really liking it.