I made sure to throw a paladin in my party because the most common complaint I see is that paladins won't be able to time their smites with crits.
This might be an unpopular opinion here, but the way Solasta does reactions is horrible. Every time I swing my sword and hit with my paladin or my cleric, I get a pop up that asks if I want to smite or strike my enemy. If it's 10 weak enemies in a battle, I'm not gonna waste spell slots and strikes on that, so I have to click pass 3 times a round minimum. [...]
Agreed that Paladin's Smite (which as @Wormerine noted, isn't actually a Reaction) should be an activated ability you use prior to attacking or a toggle. Similar for all reaction-like that you could potentially use multiple times per turn/round or on practically any ally/enemy action (e.g., Sneak Attack, Cutting Words). For your cleric's stikes...I'm seeing that these are usable 1x per turn and don't cost a resource, so I'd categorize them as similar to Sneak Attack and thus should probably also be a toggle. (Since it doesn't cost a resource and clerics don't get Extra Attack, it makes sense for it to be used automatically on your first successful attack each turn.)
+1 for a hybrid type system where, for each possible Reaction (or reaction-like ability), people can choose to leave it on "Prompt Me" / "Automatic Use" / "Don't Use"
I'll also echo the UI suggestions other have; using different-than-Solasta UI where you could e.g., just press space bar to ignore a prompt and/or it shows up on the bottom of your screen, maybe in your hotbar.