I usually pick to option "No. I'm not taking poison from a woman I can't trust."
I mean, what's even the moral dilemma here?
It's poison. That you are explicitly offered and supposed to take as a way to off yourself if things go dire.
What are we supposed to be worried about? It being too poisonous?
Anyway, it's a fairly easy promise to make for me, both because as a player I don't think we'll ever get to the point I turn into a mindflayer (and if I do it hardly matters at that point) and because in that same circumstance I'd actually think "Better dead by other means that being taken over by a random octopus dude replacing me".
If anything the real question should be: would I even get the chance to make the choice?
Chances are the moment I lost control I... well, lost control. It would be the mindflayer in my place making decisions, not me anymore.