Is it though? Draw the line for what, exactly? Where is the nuance? Nobody is asking for any NPC's to be changed or added to the world, so source material is completely respected in all cases. That's the point about the distinction that Larian controls the NPC's.
You also seem to think that any of the other examples in your list would not also be awesome possibilities. Likely to see any of it? Not really. But all three of your examples could be really awesome player characters, that create awesome stories, and generate hours of fun for only the people that should choose to make such a character without bothering any other player beyond the mere knowledge that they exist. Which is why I'm failing to see any nuance, just purity tests. Which is gross.