Over the course of two reloads:
First:
using a female warrior at level 14. I went to the barracks to talk to Alix about an escort for the healers. During the subsequent orc attack, I accidentally clicked on a soldier to attack and the rest of the barracks turned against me. So there I was surrounded by orcs and humans, all out for my blood. I managed to kill everyone around me with no potions left. I tried to make my way out of the barracks to hopefully replenish my supplies when I was struck down by the guards and orcs outside.
Second:
I go to Commander Ralph to get the Duke's murderer quest. I'm looking around in the cupboards when I see a book. I click on it and the watch descends on me for stealing. Not liking their attitude, I draw my weapon and fight my way out of the Watch's outpost, killing Ralph in the process. I managed to get out and away before quitting for the night.
I haven't checked my stats but I'm sure my reputation took a hit for that.
