Full agreement to Brainer (except that I never finished DOS2 because I got bored along the way)
It would be really bad if not selecting certain origin chars as main chars would prevent you from understanding importent parts of the main story.
Unless maybe they did it in a way that each char (including a custom one) sees a different aspect of the full picture.
Just having them in your party should be enough though.
I don´t have the time to play such a huge game 10 times.
And I try to avoid story related spoilers until I finish the game at least once.
Prof. Dr. Dr. Mad S. Tist
World leading expert of artificial stupidity.
Because there are too many people who work on artificial intelligence already
