As we escaped Irenicus's dungeon with a group of 3 companions of whom were both Jaheira and Minsc, Larian may keep secret the presence of Imoen.
For sure, she might be dead 100 years after ToB but as we know she decided to abandon Bhaal's essence at the end of ToB (that means she doesn't have to die for Bhaal's resurection, does she?),  and start her new life by reading everything she could at Candlekeep, traveling with Elminster and Khelben, building a powerfull guild of thiefs, for sure she has been able to collect a lot of knowledges and powerfull items, perhaps something big enough to beat Bhaal. So I might like to see her connected to BG3, maybe not physically but at lest as the form of her heritage, something she left behind. Whould it be through a descendant of her? / through her guil? / through her tomb? her in person? (She might have found a way to preserve herself from age after all). If i'm right, does this heritage linked to Shadowheart and her mysterious artifact?
I'm pretty excited to see if Larian decided to use her or include her in some way but in my opinion, if someone possess the key to solve the Absolute quest or a bigger problem, she has to be part of it somehow.