I think the only major things left are a day/night system (which is unlikely), a way to pass conversations and skill checks to other party members, and multiclassing (we've had no word on that for a while).
Depends on what one considers "major," doesn't it? For me, in addition, to these things, there are also: the party movement mechanic (which is extremely aggravating); a minimum of three good-aligned companions; option to increase party size up to six; a comprehensive system for tailoring gameplay and difficulty settings; a built-in mod manager system; revamped and more user-friendly UIs; custom PC being more central to the party and the game; good-aligned roleplaying choices getting equivalent benefits to the evil side (ex. benefits for NOT using the tadpole); more realistic options within dialogues, including a wider range of options for what a custom PC gets to say in interactions with the origin companions (ex, being able to comment, including harshly, on being a vampire, a Sharran, making a pact with a devil, etc.); a real and meaningful connection to the original games, and not merely superficial connections such as bringing in a couple of old characters.