If you twin spell a single-target non-damaging spell, such as hold person or tasha's laughter, it uses the same awful targeting setup as Bless/Bane where you cannot choose targets, it just picks the closest creature. This is really fun since it will happily target allied creatures if they stand between two enemies. Even if no allies get in the way, you cannot target the enemies you want in many cases.
Every "X Targets" spell in this game should let you pick each target individually, similarly to how Scorching Ray works.